The modern men and women of today are fast becoming aware of the benefits of exercise and proper diet, which includes taking the right anti aging healthy dietary supplements, reading more about health and nutrition, the effects and value of embarking on a lifestyle change, indulging in HGH stimulating fitness routines, and picking the right shape up healthy diet meal plan. Antioxidants are the extracellular circulating and membrane bound free radical scavengers that keep us from suffering the effects of aging such as the age related diseases and of course, the aesthetic destructive appearance of wrinkles and deep lines on the face. The action of the antioxidants is mostly focused on the prevention of damage, interception of free radicals, and repair of cells on an enzymatic level specifically the DNA repair system. The damage to cells are often caused by free radicals, which should be carefully considered in our aging skin care rejuvenation treatments and also, in preventing the progression of any age related diseases. The antioxidants are our first line of defense against the free radical damage. It is also important in maintaining our optimum health and well-being. As we grow older, we are more exposed to the hazards of our environment. In our day-to-day interaction with the outside world, we collect free radicals and toxins from our increased exposure to cigarette smoke, pollution, stress, and other microorganisms. There are so many factors contributing to oxidative stress and diseases. This makes susceptibility and prevention a clear priority and a major factor to stay happy and healthy.
Our perception about vitamins against our need to sustain a healthy body: Are they making us healthy or sick?
If you see most researchers characterized the vitamins and minerals, the cosmetic industry has been advertising the power antioxidants intensively of their ability to decrease or delay aging by highlighting their influence on the delay or reduction of the general oxidation process. The antioxidants inhibit the reactive oxygen and nitrogen species, which result in adversely affecting the normal physiological and biological functions of the human body. Examples of physiologically active antioxidants are the enzymes, such as the glutathione peroxidases and superoxide dismutases and the catalases. Examples of the non-enzymatic antioxidants are the glutathione, thiols, vitamins, metals, and the phytochemicals. The polyphenols, isoflavones, and the flavonoids are examples of phytochemicals. Diets high in fruits and vegetables have long been associated with the decreasing risk of developing cancer. The antioxidants they contained have long been identified as the bioactive component providing this benefit. For growth and survival, our body needs dietary antioxidants such as the Vitamins A, C, and E, carotenoids, beta-carotene, and the endogenous antioxidant enzymes. The glutathione, coenzyme Q10, alpha lipoic acid, L-Carnitine, NADH, B Vitamins, and certain minerals are important antioxidant enzymes we need for growth and survival. The distribution of these antioxidants varies within cells and organs.
Free radicals, aging, diseases, and oxidative stress
Nowadays, the implications of free radicals have been associated with the increasing number of human diseases. Noting the mechanism of the free radicals among human beings, we could say that oxidized compounds are often reactive and become a secondary messenger of oxidative stress. They are biologically reactive even if they are not chemically reactive. The lymphocytes recognized the free radicals’ endogenous product as an antigen, which creates non-specific auto antibodies that results in tissue damage. The free radicals produce stress induced damage in the forms of oxidized proteins, oxidized DNA auto antibodies, and many others. The free radical stress comes as a result of the free radical production and antioxidant system imbalance. The theory of aging and the damages brought by the oxidative stress is truly closely associated with each other.
In the free radical theory of aging, the person’s level of oxidative stress increases as the age increases. There seems to be an accumulation of oxidation products in the lipids, proteins, nucleic acids, sugars, and sterols resulting in ultimate cellular dysfunction. The oxidative damage in the mitochondrial DNA triggers senescence. There is one hypothesis about the oxidative stress in aging predicting the progression of the aging process to retard the lifespan. However, reduction of the oxidant production by enhancing the body’s antioxidant defenses, which results in the augmentation of the cells’ repair capabilities is very possible using antioxidants in the form of supplements or diet alteration.
Favier, A. E. (1995). Analysis of free radicals in biological systems. Switzerland: Springer.
Miwa, S., Beckman, K. B. & Muller, F. L. (2008). Oxidative stress in aging from model systems to human diseases. NJ: Springer.
Prasad, K. N. (2011). Micronutrients in health and disease. Boca Raton, FL: CRC Press.
Panglossi, H. V. (2006). New developments in antioxidants research. New York: Nova Science Publishers Inc.